Latest results from the PACE Trial: CBT and Graded Exercise now found to be ‘the most cost-effective treatments for ME/CFS’ | 1 August 2012

August 1, 2012

Medical Research Council press release issued this afternoon but embargoed until 10pm. The full paper can be read in PlosOne HERE

Two treatments found previously to be the most effective for patients with Chronic Fatigue Syndrome or Myalgic Encephalomyelitis (CFS/ME) have now been found to be the most cost-effective treatments evaluated in a large clinical trial.

The latest results from the PACE trial show that both cognitive behaviour therapy (CBT) and graded exercise therapy (GET), as supplements to specialist medical care, offer good value for money for healthcare providers when the cost of treatment is weighed up against improvement in quality of life.

CBT and GET were found to be even more cost-effective when the savings to wider society – through a reduced need for additional care by family members – were taken into account. Adaptive pacing therapy (APT) was not cost-effective. The research was led by King’s College London, the University of Oxford and Queen Mary, University of London , and was funded by the Medical Research Council (MRC), National Institute for Health Research (NIHR) and UK government departments.

The researchers drew their conclusions in line with healthcare cost criteria used by NICE (National Institute for Health and Clinical Excellence), which considers treatments costing less than £20,000 to £30,000 per year lived in good health (known as a quality-adjusted life years, or QALYs) to represent value for money.

Professor Paul McCrone, a health economist from King’s College London’s Institute of Psychiatry and lead author of the paper, said:

“It’s very encouraging that two treatments found to help a significant number of CFS/ME patients are also cost-effective based on existing NICE criteria. There is now a strong case for the NHS to invest in providing these therapies. Our research suggests this investment would be justified in terms of improving quality of life for patients and could actually save costs to society if the impact on family members is taken into account.”

Professor Michael Sharpe from Oxford University and a co-author of the paper said:

“In the PACE trial we found that the rehabilitative treatments CBT and GET improve the fatigue and disability of people with CFS/ME. This new analysis of the trial data finds that these treatments are also cost-effective in improving patients’ quality of life. They are potentially cost-saving to society if the time of family and carers is also considered. This new evidence should encourage health service commissioners to provide these treatments to all those patients who need them.”

Professor David Lomas, Chair of the MRC Population and Systems Medicine Board, which co-funded the PACE trial, said:

“CFS/ME has a profound effect on patients and can severely impact their quality of life. These promising findings demonstrate how MRC funding can help to identify treatments that are not only effective, but are financially viable for the health service. There is still a pressing need to understand more about the underlying causes of CFS/ME and we recently announced a further £1.6m of funding for this purpose in the hope it will lead to new diagnostic tools and treatments.”

CFS/ME is a long-term, complex and debilitating condition that affects around 250,000 people in the UK , including children. Symptoms include profound physical and mental fatigue, muscle and joint pain, disturbed sleep patterns and concentration and memory problems. The combination and severity of symptoms varies from patient to patient, making it a difficult condition to diagnose and treat.

In 2011, the first findings from the PACE trial showed that CBT and GET benefit around 60 per cent of patients with CFS/ME, for whom fatigue was the main symptom. The latest study, published in the journal PLOS ONE, compared the cost-effectiveness of each treatment after one year against the criteria used by the NHS watchdog NICE. The researchers looked at the total cost of each course of treatment to the NHS and to wider society through patients requiring time off work and informal care from friends and relatives.

Specialist medical care was the cheapest option in terms of absolute cost to provide, but when the benefit of treatment on quality of life was taken into account, CBT became the most cost-effective option (likelihood of 62.7 per cent). There was a 26.8 per cent likelihood that GET was the most cost effective, while the likelihood for APT and standard care alone were 2.6 and 7.9 per cent, respectively.

The PACE trial was funded by the MRC, National Institute for Health Research, Chief Scientist Office, Scotland, and Department for Work and Pensions.

7 thoughts on “Latest results from the PACE Trial: CBT and Graded Exercise now found to be ‘the most cost-effective treatments for ME/CFS’ | 1 August 2012”

  1. “In 2011, the first findings from the PACE trial showed that CBT and GET benefit around 60 per cent of patients with CFS/ME, for whom fatigue was the main symptom.” This is misleading of them to say without putting some context on it. By the post-hoc* definition they used for benefit, the figure for SMC (=no management therapy, could be called a control group) is 45%.

    * post-hoc means they didn’t say in the protocol they were going to use this method; they decided to use it after all the data was collected and the trial was finished.

  2. Oh for goodness’ sake, do these people bother to look into the details? No, of course not. It’s about saving money on non-treatment that actually makes a lot of people much worse. It killed Sophia and Lynn, and that’s just in my town.

    Invest in ME made a concise critique of PACE on PlosONE:

    Here is a meta-analysis of harms from such treatments, over 4338 individuals subjected to GET, over half, 2223, reported that the ‘therapy’ had harmed them. See the table on the last page

    I can’t believe that the MEA has published this biased press release without comment. Perhaps you were leaving it to us?

  3. The MRC is shameful, one minute acknowledging ME to be the serious illness it is – in their – albeit extremely tardy – request for more biomedical research applications – then trotting out this abject nonsense. Am left speechless. ‘Lies, damned lies, and statistics’ very much comes to mind.

    1. That’s just it. They don’t really acknowledge ME at all. The money that was recently awarded is to be spent on fatigued people, which includes fatigue in Hep C. They don’t recognise ME. They are not spending a any money on ME.

  4. Oh for God’s sake, here we go again. Will it never end?
    It all fits in very conveniently with the government’s assault on benefits, just stuff all the people in the WRAG group on GE/CBT and if they don’t get better, well it’s their “false illness beliefs”, isn’t it…..
    I’m so, so sick of this.

    Good response from MEA, thank you Dr Shepherd.

  5. Same old story thousands of people who desperately need some help being left to rot by the medical profession

    although I have been given some antidepressants !

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