TGI Friday! | Our weekly round-up of recently published research abstracts | 4 November 2016

November 3, 2016

From the Journal of Health Psychology, 1 November 2016 (open access)

‘PACE-Gate’: When clinical trial evidence meets open data access

Keith J Geraghty
Centre for Primary Care, The University of Manchester, 7th Floor, Williamson Building, Oxford Road, Manchester M13 9PL, UK. Email:


Science is not always plain sailing and sometimes the voyage is across an angry sea. A recent clinical trial of treatments for chronic fatigue syndrome (the PACE trial) has whipped up a storm of controversy.

Patients claim the lead authors overstated the effectiveness of cognitive behavioural therapy and graded exercise therapy by lowering the thresholds they used to determine improvement.

In this extraordinary case, patients discovered that the treatments tested had much lower efficacy after an information tribunal ordered the release of data from the PACE trial to a patient who had requested access using a freedom of information request.

2 thoughts on “TGI Friday! | Our weekly round-up of recently published research abstracts | 4 November 2016”

  1. Great to see a cracking paper in a mainstream journal. Many thanks to Keith. Hoping that many health-care professional read it.

    Meanwhile, jaw-dropping news from Disability News Service, and a book recommendation for disabled WRAF veteran Mo Stewart’s book “Cash not Care: the planned demolition of the Welfare State”. Eye-opening for those new to the dire and shocking circumstances that those of us who have been ill for a very long time are all too aware of.


  2. I agree that this is a brilliant paper. I wish that somebody at the top in NHS and NICE would see it too so that no more money is wasted on research into the biopsychosocial model of ME/CFS. I hope that Stephen Holgate and the whole MEGA team will read it too. Hopefully then they will understand better some of the recent patients reactions to the MEGA project idea.

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