Medical Matters > Blood Test: Antinuclear Antibody (ANA)

ME Essential Winter 2017


I have a new and very thorough GP who has decided to thoroughly re-assess my state of health. So he arranged for a number of blood tests – some of which are not usually used to diagnose ME/CFS but are referred to in the investigation section of the MEA purple book. Everything is normal – apart from me having an ANA positive result with a low antibody titre. What does this mean? Should I be concerned?


The ANA blood test measures the level of what are called antinuclear antibodies in the blood. This is a type of antibody that is made by the body’s immune system and can occur in what are called autoimmune diseases that often involve some form of inflammation. Examples include lupus/ SLE, rheumatoid arthritis, antiphospholipid syndrome and Sjogren’s syndrome – all of which have symptoms that can overlap with ME/CFS, and may be misdiagnosed as ME/CFS. So, an ANA test can be positive in a range of conditions – which ought to be excluded by your doctor taking a very careful clinical history, a full physical examination and possibly arranging some further blood tests.

However, an ANA test can also be positive in perfectly healthy people and with some types of medication. As you may know, low levels of various autoantibodies, including ANA, are also sometimes found in people with ME/ CFS. This is why the term ‘autoimmune component’ is sometimes used in terminology for ME/CFS. Where the ANA level is low, and there is no reason to link it to a specific cause, all that may be required is to repeat the test at intervals and continue to review the situation.

For example – I am in contact with someone at the moment who developed mild joint pains, had a slightly raised ANA but did not have any other laboratory or clinical evidence of an ANA-related condition. An anti-inflammatory drug was prescribed and the symptoms settled down and the ANA level returned to normal.

I think you need to discuss the result of your test with your doctor, ask why they think the ANA level is raised and how this is going to be managed. If there are any concerns that it may be related to another medical condition you could be referred to a hospital physician or an immunologist for further assessment.

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Medical Matters is for information purposes only. The answers provided by Dr Shepherd and the ME Association’s other expert advisers should not be construed as medical advice. We recommend that any information you deem relevant is discussed with your GP as soon as possible. It is important to obtain advice from a GP who is in charge of your clinical care, who knows you well, and who can consider other likely causes for symptoms. Seek personalised medical advice whenever a new symptom arises, or an existing symptom worsens. Don't assume that new or worsened symptoms are a result of having ME/CFS.

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