Research | XMRV developments disappointing but provide valuable lessons to would-be microbe hunters | 18 July 2012

From Current Opinion in Virology, published online 18 July 2012 (full text behind paywall).

Recombinant origin, contamination, and de-discovery of XMRV

Krista Delviks-Frankenberry(1), Oya Cingöz(2), John M Coffin(2), Vinay K Pathak(1),
(1) Viral Mutation Section, NCI, HIV DRP, Frederick National Laboratory for Cancer Research, Frederick, MD, United States
(2) Program in Genetics, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA, United States

Abstract

The discovery and de-discovery of the xenotropic murine leukaemia virus-related virus (XMRV) has been a tumultuous roller-coaster ride for scientists and patients.

The initial associations of XMRV with chronic fatigue syndrome and prostate cancer, while providing much hope and optimism, have now been discredited and/or retracted following overwhelming evidence that (1) numerous patient cohorts from around the world are XMRV-negative, (2) the initial reports of XMRV-positive patients were due to contamination with mouse DNA, XMRV plasmid DNA, or virus from the 22Rv1 cell line and (3) XMRV is a laboratory-derived virus generated in the mid 1990s through recombination during passage of a prostate tumor xenograft in immuno-compromised mice.

While these developments are disappointing to scientists and patients, they provide a valuable road map of potential pitfalls to the would-be microbe hunters.

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