Research, multi-centre trial | Treatment of CFS and Fibromyalgia with D-ribose | 4 July 2012

From The Open Pain Journal, 4 July 2012

Treatment of Chronic Fatigue Syndrome and Fibromyalgia with D-Ribose – An Open-label, Multicenter Study.

Jacob Teitelbaum, Janelle Jandrain and Ryan McGrew Pp 32-37
(Academic affiliations not stated)


OBJECTIVES: Chronic Fatigue Syndrome and Fibromyalgia (CFS/FMS) are debilitating syndromes affecting ~2- 4% of the population. Although they are heterogeneous conditions associated with many triggers, they appear to have the common pathology of being associated with impaired energy metabolism.

As D-ribose has been shown to increase cellular energy synthesis, and was shown to significantly improve clinical outcomes in CFS/FMS in an earlier study, we hypothesized that giving D-ribose would improve function in CFS/FMS patients.

DESIGN, LOCATION AND SUBJECTS: An open-label, unblinded study in which 53 US clinics enrolled 257 patients who had been given a diagnosis of CFS/FMS by a health practitioner.

INTERVENTIONS: All subjects were given D-ribose (Corvalen™), a naturally occurring pentose carbohydrate, 5-g TID for 3 weeks.

OUTCOME MEASURES: All patients were assessed at baseline (1 week before treatment), and after 1,2, & 3 weeks using a Visual Analog Scale(1-7 points) rating energy, sleep, cognitive function, pain and overall well being.

RESULTS: 203 patients completed the 3 week treatment trial. D-ribose treatment led to both statistically(p<.0001) and clinically highly important average improvements in all categories: • 61.3 % increase in energy • 37% increase in overall well being • 29.3% improvement in sleep • 30% improvement in mental clarity • 15.6% decrease in pain Improvement began in the first week of treatment, and continued to increase at the end of the 3 weeks of treatment. The D-ribose was well tolerated. CONCLUSIONS: In this multicenter study, D-ribose resulted in markedly improved energy levels, sleep, mental clarity, pain relief, and well being in patients suffering from fibromyalgia and chronic fatigue syndrome. NCT01108549


0344 576 5326

Available every day of the week between these times: 10am - 12noon, 2pm - 4pm and 7pm - 9pm.

Calls cost the same as other standard landline numbers (starting 01 or 02). If you have a call package for your landline or mobile phone then calls will normally come out of your inclusive minutes.