NICE Guideline > Fatigue

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Fatigue in ME/CFS typically has the following components:

  • - feeling flu-like, especially in the early days of the illness.
  • - restlessness or feeling 'wired but tired'.
  • - low energy or a lack of physical energy to start or finish activities of daily living and the sensation of being 'physically drained'.
  • - cognitive fatigue that worsens existing difficulties.
  • - rapid loss of muscle strength or stamina after starting an activity, causing for example, sudden weakness, clumsiness, lack of coordination, and being unable to repeat physical effort consistently.
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