Medical Matters > Stress and ME/CFS

ME Essential Summer 2017


When I first developed ME, this was triggered by an infection. But I was also under a lot of physical stress (at work) and mental stress (at home) at the time. I know that ME isn’t just another type of stress disorder but stress does seem to play a role in both triggering and causing exacerbations in some people with ME. So what do we know about the role of stress in ME? And has there been any research into the role of stress?


There are two important points to note:

Chronic stress can disrupt the hypothalamic-pituitary-adrenal axis (an important method of hormone feedback and control) and the production of the stress hormone cortisol from the adrenal glands. So when a significant acute stressor then appears, like an infection, a past or current history of chronic stress could be creating fertile ground for an infection to trigger ME/CFS.

In addition, once ME/CFS has occurred, any form of ongoing chronic stress, or even an acutely stressful episode — relating to problems with doctors, family, benefits, finances, etc – is probably going to have a negative impact on any possible recovery process in ME/ CFS. It could also trigger a relapse or exacerbation of symptoms. Where stress is present, these factors do need to be addressed in the overall management of ME/CFS. The role of stress and immune system stressors – acute and chronic – on the body cannot, therefore, be ignored in ME/CFS. And this is clearly an area where useful research could be carried out.

More information


Information provided by The ME Association should not be construed as medical advice. Don't assume any new or worsened symptoms are simply the result of having ME/CFS or Long Covid. We recommend that any information you deem relevant is discussed with your NHS GP as soon as possible. It is important that you seek personalised medical advice from the GP who is in charge of your care and who knows you well.

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