Margaret became ill with ME/CFS in 1989 after coming into contact with sheep dip on her farm. She was an elected hereditary peer and a crossbench member of the House of Lords where she held a number of distinguished positions, including Deputy Speaker and Deputy Chair of Committees. She became Deputy Chair of the All-Party Parliamentary Group on ME (APPG), established and chaired Forward-ME and has had a distinguished career advocating for ME/CFS. Her passionate and effective campaigning won widespread support from the patient community. She became a patron of the charity in 2015 and retired from public service in 2021.