From Antioxidants & Redox Signalling, 11 November 2014.
Does oral Coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in Chronic Fatigue Syndrome?
Dr. Jesus Castro-Marrero, Ph.D.(1), Prof. Mario D. Cordero (2), Dr. Maria Jose Segundo (3), Naia Saez-Francas (4), Dr. Natalia Calvo (5), Dr. Lourdes Román-Malo (2), Luisa Aliste (1), Prof. Tomas Fernandez de Sevilla (1), Dr. Jose Alegre-Martin (1)
1) Vall de Hebron Univ Hospital Research Institute, CFS Research Unit, Passeig de Vall de Hebron, 119-129, Barcelona, Spain firstname.lastname@example.org
2) Research Laboratory, Dental School, Universidad de Sevilla, Sevilla, Spain
3) Vitae Natural Nutrition, SL, Research and Development (R&D), Barcelona, Sant Cugat del Vallès, Spain;
4) Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Departamento de Psiquiatría y Medicina Legal, Barcelona, Spain;
5) Vall d’Hebron University Hospital, Departamento de Psiquiatría y Medicina Legal, Barcelona, Spain;
Chronic Fatigue Syndrome (CFS) is a chronic and extremely debilitating illness characterized by prolonged fatigue and multiple symptoms with unknown cause, diagnostic test, or universally effective treatment.
Inflammation, oxidative stress, mitochondrial dysfunction, and CoQ10 deficiency have been well documented in CFS. We conducted an 8-weeks randomized, double-blind, placebo-controlled trial to evaluate the benefits of oral CoQ10 (200 mg/day) plus NADH (20 mg/day) supplementation on fatigue and biochemical parameters in 73 Spanish CFS patients.
This study was registered in ClinicalTrials.gov (NCT02063126).
A significant improvement of fatigue showing a reduction in FIS total score (p< 0.05) was reported in treated group vs. placebo. In addition, a recovery of the biochemical parameters was also reported. NAD+/NADH (p< 0.001), CoQ10 (p< 0.05), ATP (p< 0.05) and citrate synthase (p< 0.05) were significantly higher and lipoperoxides (p< 0.05) were significantly lower in blood mononuclear cells (BMCs) of the treated group. These observations lead to the hypothesis that the oral CoQ10 plus NADH supplementation could confers potential therapeutic benefits on fatigue and biochemical parameters in CFS. Larger sample trials are warranted to confirm these findings.