Medical Matters > Can HIV/AIDS be misdiagnosed as ME/CFS?

ME Essential Winter 2025

Question

I’ve been diagnosed with ME by my GP after having several months of fatigue, enlarged glands, night sweats and flu-like symptoms. A friend says that HIV/AIDS can cause very similar symptoms in the early stages and that I probably ought to have an HIV blood test – which hasn’t been done as far as I know.

Having had several sexual partners, some casual, in the past, I suppose I could be at risk. Unfortunately, this isn’t the sort of medical query that I can discuss with my GP because he is a family friend.

Answer

Firstly, it's worth noting that all doctors have a duty of strict confidentiality to their patients – which means that sensitive medical information must not be disclosed to members of your family (or anyone else) without your knowledge or permission. But I do understand your concerns.

Secondly, your question is very valid – because HIV (and hepatitis C infection) can cause persisting flulike symptoms, especially during the early stages. So testing for these infections should form part of a routine assessment in anyone who is suspected of having ME/CFS, especially where a person has had multiple sexual partners, or has been involved in other ‘at risk' behaviour (e.g. intravenous drug use) or has had a blood transfusion prior to 1992 (in relation to hepatitis C infection).

If you feel that you cannot talk to your GP about having an HIV test you can make an appointment at a local genito-urinary medicine clinic – most local hospitals have one. There may also be a local private clinic that does HIV testing and counselling.

Early/Acute HIV Symptoms (2-6 weeks after infection):

  • Fever: A common symptom, often accompanied by other flu-like symptoms.
  • Sore Throat: Inflammation and discomfort in the throat.
  • Swollen Lymph Nodes: Enlarged glands, particularly in the neck, armpits, and groin.
  • Muscle and Joint Pain: Aches and pains throughout the body.
  • Rash: Skin eruptions or lesions may occur.
  • Fatigue: Feeling tired and lacking energy.
  • Headache: A common symptom, sometimes severe.
  • Diarrhoea: Loose stools and frequent bowel movements.
  • Mouth Ulcers: Sores or lesions in the mouth.
  • Night Sweats: Excessive sweating during sleep.

Later Stage HIV Symptoms:

  • Weight Loss: Unexplained and significant weight loss.
  • Chronic Diarrhoea: Persistent and prolonged diarrhoea.
  • Oral Thrush: Fungal infection in the mouth, causing white patches.
  • Recurrent Infections: Frequent or persistent infections such as pneumonia, tuberculosis, or skin infections.
  • Swollen Lymph Nodes: Can persist or worsen.
  • Neurological Problems: Cognitive impairment, memory loss, or other neurological issues.
  • Skin Problems: Rashes, lesions, or other skin conditions.

See Also: Testing: HIV

MEDICAL DISCLAIMER

We recommend that the medical information is discussed with your doctor. It is not intended to be a substitute for personalised medical advice or treatment. You should consult your doctor whenever a new symptom arises, or an existing symptom worsens. It is important to obtain medical advice that considers other causes and possible treatments. Do not assume that new or worsened symptoms are solely because of ME/CFS or Long Covid.

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