Medical Matters > Symptom: Nerve Pain

ME Essential Winter 2020


Like most people with ME/CFS, pain is a fairly constant and frustrating symptom. But this has become more persistent and severe over the past few months. My GP has prescribed various pain relieving drugs – including low doses of amitriptyline and gabapentin – none of which has had much effect. As well as the pain, which often has a burning quality to it, the areas around it sometimes feel numb and strange. I’m starting to feel quite depressed as a result – is there anything else that could be done to help?


From your description, it sounds as though you may be experiencing neuropathic or nerve pain which can also be a symptom of peripheral neuropathy. A useful way for doctors to confirm a diagnosis of nerve pain is by using a screening tool called the Leeds Assessment of Neuropathic Symptoms and Signs. Over-the-counter painkillers are seldom effective for this type of pain, but there are a number of prescription-only drugs that can be effective, often at low doses, that may be worth trying. These include amitriptyline, duloxetine/Cymbalta, gabapentin/ Neurontin and pregabalin/Lyrica. Tramadol, which is also sometimes prescribed for pain relief in ME/CFS, is more suitable for short-term acute rescue situations.

The NHS: Peripheral Neuropathy

Overview, Symptoms, Causes, Diagnosis, Treatment, Complications | April 2022

Peripheral neuropathy develops when nerves in the body's extremities, such as the hands, feet and arms, are damaged. The symptoms depend on which nerves are affected. The peripheral nervous system is the network of nerves that lie outside the central nervous system (the brain and spinal cord). It includes different types of nerves with their own specific functions, including:

    • sensory nerves – responsible for transmitting sensations, such as pain and touch
    • motor nerves – responsible for controlling muscles
    • autonomic nerves – responsible for regulating automatic functions of the body, such as blood pressure and bladder function

The main symptoms of peripheral neuropathy can include:

    • numbness and tingling in the feet or hands
    • burning, stabbing or shooting pain in affected areas
    • loss of balance and co-ordination
    • muscle weakness, especially in the feet

These symptoms are usually constant, but may come and go.

The main types of peripheral neuropathy include:

    • sensory neuropathy – damage to the nerves that carry messages of touch, temperature, pain and other sensations to the brain
    • motor neuropathy – damage to the nerves that control movement
    • autonomic neuropathy – damage to the nerves that control involuntary bodily processes, such as digestion, bladder function and control of blood pressure
    • mononeuropathy – damage to a single nerve outside of the central nervous system

In many cases, someone with peripheral neuropathy may have more than one of these types of peripheral neuropathy at the same time.

Relieving nerve pain


You may also require medicine to treat any nerve pain (neuropathic pain) you're experiencing. Unlike most other types of pain, neuropathic pain does not usually get better with common painkillers, such as paracetamol and ibuprofen, and other medicines are often used. These should usually be started at the minimum dose, with the dose gradually increased until you notice an effect. Higher doses may be better at managing the pain but are also more likely to cause side effects.

Many of these medicines may also be used for treating other health conditions, such as depression, epilepsy, anxiety, or headaches. If you're given an antidepressant, this may treat pain even if you're not depressed. This does not mean your doctor suspects you're depressed. The main medicines recommended for neuropathic pain include:

    • amitriptyline – also used for treatment of headaches and depression,
    • duloxetine – also used for treatment of bladder problems and depression,
    • pregabalin and gabapentin – also used to treat epilepsy, headaches, or anxiety.

There are also some additional medicines that you can take to relieve pain in a specific area of your body or to relieve particularly severe pain for short periods.

Capsaicin cream

If your pain is confined to a particular area of your body, you may benefit from using capsaicin cream. Capsaicin is the substance that makes chilli peppers hot and is thought to work in neuropathic pain by stopping the nerves sending pain messages to the brain. Rub a pea-sized amount of capsaicin cream on the painful area of skin 3 or 4 times a day. Side effects of capsaicin cream can include skin irritation and a burning sensation in the treated area at the start of treatment. Do not use capsaicin cream on broken or inflamed skin, and always wash your hands after applying it.


Tramadol is a powerful painkiller related to morphine that can be used to treat neuropathic pain that does not respond to other treatments your GP can prescribe. Like all opioids, tramadol can be addictive if it's taken for a long time. It'll usually only be prescribed for a short time. Tramadol can be useful to take at times when your pain is worse.

More information


Information provided by The ME Association should not be construed as medical advice. Don't assume any new or worsened symptoms are simply the result of having ME/CFS or Long Covid. We recommend that any information you deem relevant is discussed with your NHS GP as soon as possible. It is important that you seek personalised medical advice from the GP who is in charge of your care and who knows you well.

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