Referrals are triaged by specialist clinicians in the service, and if appropriate, patients are invited to attend an initial assessment with a specialist clinician. At the appointment, patients are assessed, and a diagnosis is confirmed based on the preliminary diagnosis from the referring GP.

Information and advice for self-management of the condition are person-centred and delivered through education sessions, therapy interventions, and self-help literature. Areas covered (amongst others) include education regarding the symptomology of ME/CFS, understanding energy, activity management, relaxation, sleep, stress, and emotional well-being.

Clinical and therapy appointments are offered virtually (via video link or telephone). If preferred, face-to-face appointments can be offered at clinics in Peterborough (Botolph Bridge Community Health Centre), Huntingdon (Hinchingbrooke Hospital), and Cambridge (Brookfield Hospital).