Supplements – Muscle Energy


In this leaflet we consider exertion-induced muscle fatigue and other muscle symptoms, and examine the effectiveness of the supplements that are marketed as being able to increase muscle energy.


Exertion-induced muscle fatigue is a key symptom of M.E. It is often accompanied by weakness, pain, aches, and twitching (fasciculations) in the muscle.

So it’s not surprising that people believe there is a major problem in the way that their muscles are producing energy during activity.

The view of most doctors is that M.E. could involve both brain fatigue as well as muscle fatigue – although current evidence suggests that central/brain factors are more important than peripheral/muscle factors.

Muscle-energy supplements are naturally-occurring substances that assist in the production of energy at a cellular level, especially in muscle.

Those considered in this leaflet are available as commercial products. They are normally classified as supplements rather than medicines because there is very limited evidence for making medical claims about their effectiveness in M.E.

Dr Charles Shepherd (Hon. Medical Adviser to the ME Association) explains what each supplement can do and helps determine if these supplements might have a use in the relief of muscle symptoms.

Telephone Helpline

The ME Association telephone helpline – ME Connect – is available every day of the year, during the hours of 10am-12noon, 2pm-4pm and 7pm-9pm. Please phone: 0344 576 5326 if you have any questions or would simply like to talk to someone who is there to listen.

Please note this leaflet is a download. You can read it on-screen and save to your computer, phone or other device and can attach it to any email you might need to send. But you will need access to a printer if you wish it printed.


0344 576 5326

Available every day of the week between these times: 10am - 12noon, 2pm - 4pm and 7pm - 9pm.

Calls cost the same as other standard landline numbers (starting 01 or 02). If you have a call package for your landline or mobile phone then calls will normally come out of your inclusive minutes.