Drugs – Lyrica (Pregabalin): Moderate to Severe Pain Relief


This detailed leaflet talks about pain in M.E. and how it can be managed. It features the drug Lyrica and reviews the evidence for its use as a pain relief medication.

What is Lyrica?

Lyrica (Pregabalin = generic name) is a drug that can be used to treat three different conditions – epilepsy, nerve pain and anxiety. In relation to pain, it is used for moderate or severe pain, especially nerve (neuropathic) pain, that is persistent and which has not responded to other types of painkillers. Lyrica can be used alone or in combination with some other types of painkiller.

New Prescribing Guidelines

Due to growing concerns about misuse, the legal status of Lyrica has changed and these changes came into effect in April 2019. This drug is now classified as a Class C Controlled Drug… and as a result, some doctors are likely to take a far more cautious view about prescribing Lyrica for pain relief in ME/CFS.

Telephone Helpline

The ME Association telephone helpline – ME Connect – is available every day of the year, during the hours of 10am-12noon, 2pm-4pm and 7pm-9pm. Please phone: 0344 576 5326 if you have any questions or would simply like to talk to someone who is there to listen.

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